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Non-binding residues show significant protections. a, residue level extent of oxidation of Robo1 alone (black bars) compared with heparin-bound Robo1 (gray bars) for residues Cys147, Met180, and Met189. Error bars, S.D. from a triplicate set of experiments. b, structural model showing Cys147 (yellow) involved in the disulfide bond with Cys89 in Ig1 domain. c, hydrophobic residues Met180 and Met189 are shown in yellow in the Ig2 domain of Robo1.
