FIGURE 4.

Combined schematic representations of the MurU structure (same orientation as Fig. 1) as well as those of the structurally related Glc-1-P thymidylyltransferase RmlA (P. aeruginosa; Protein Data Bank code 1G1L), GlcNAc uridylyltransferase GlmU (E. coli; Protein Data Bank code 1FWY), and Man-1-P guanylyltransferase GMPase (T. maritima; Protein Data Bank code 2X5Z) structures. All four proteins are shown with a semitransparent surface. Of the multimeric enzymes RmlA^P.a., GlmU^E.c., and GMPase^T.m. only one monomer is depicted. The coloring highlights similarities in domain organization: blue, C-terminal domain; orange, sugar-binding domain; marine blue, SNT signature motif. Note that, despite the obvious structural similarities, the sequence identities of these enzymes to MurU are quite low (RmlA; 22.6%; GlmU, 16.6%; GMPase, 18.7%).