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. 2015 Mar 10;290(17):10862–10875. doi: 10.1074/jbc.M114.616029

FIGURE 6.

FIGURE 6.

Effect of DMMTC on Tau aggregation in cells co-expressing constitutive SSTau(190–441) and inducible, full-length hTau40. Prior to induction with IPTG, and in the absence of DMMTC, there are baseline levels of hTau40 expressed in cells as well as low levels of SSTau(190–441) and its 25-kDa truncation product. When induced with IPTG alone, hTau40 expression was increased together with the amount of the 40- and 25-kDa Tau truncation products. Butyrate induction alone (not shown) or induction with both IPTG and butyrate increased the level of the 25-kDa truncation product. In the presence of DMMTC, the capture of full-length Tau and its conversion to the 25-kDa species was inhibited following either IPTG induction or induction with both IPTG and butyrate. U, uninduced; I, IPTG-induced; B, butyrate-induced.