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Model for δ-catenin-mediated regulation of synaptic architecture. A, δ-catenin promotes the trafficking and stabilization of N-cadherin at synapses. B, stabilization of the N-cadherin-δ-catenin complex allows δ-catenin to recruit and stabilize PDZ domain-containing proteins that modulate the spine actin cytoskeleton via effectors to influence spine architecture.
