FIGURE 6.

EM analysis. Representative EM images of the three fibrillar morphologies found in H₂O₂-oxidized apoA-I samples. Convoluted fibrillar tangles (A), individual threads (B), and rods (C). The three morphologies often coexisted in the same sample. Similar morphologies were observed in MPO-oxidized samples. D, thread-like structure in MPO-3:1-H₂O₂-oxidized apoA-I. Negative staining EM micrographs were obtained after 24 h incubation under fibrillation conditions. Mean width of amyloid fibrils in each micrograph and S.E. are reported.