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. 2015 Mar 12;290(17):11041–11051. doi: 10.1074/jbc.M115.640169

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Response of the CCR5/CCR2b receptor chimeras to chemokines and inhibition by SCH-C. A, chemokine-mediated calcium flux response to the CCR5 chemokine RANTES by 2252, 2255, and wild-type CCR5. B, chemokine-mediated calcium flux response to the CCR2b chemokine MCP-1 by the chimera 2252 and wild-type CCR2b. C, inhibition of the receptor chimeras 2252 and 2255 and wild-type receptors CCR2b and CCR5 by the CCR5 antagonist SCH-C. The chimeras and CCR5 were stimulated with RANTES, and CCR2b was stimulated with MCP-1. Error bars represent S.E. RFU, relative fluorescence units.