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Two docked binding modes of SCH-C in the maraviroc binding site of CCR5. A, the ethyl oxime group points toward the extracellular region, and the bromophenyl group points into the center of the transmembrane domain. B, the oxime and the bromophenyl group are rotated by 180°. In both potential binding modes, SCH-C is able to form a non-polar interaction with Ile198. For clarity, TM-IV and the extracellular part of TM-III (residues 98–106) are not shown.
