TABLE 3.

Effect of mutating Ile¹⁹⁸ of human CCR5 on inhibition of RANTES ligand binding and CCR5/gp120 cell fusion by SCH-C and TAK-779

Results are expressed as IC₅₀ (nm) ± S.E.

	RANTES binding			Cell fusion
	CCR5 WT	I198A	I198M	CCR5 WT	I198A	I198M
SCH-C	43.0 ± 2.7 (n = 9)	396.7 ± 121.7 (n = 3)	911.3 ± 61.5 (n = 34)	3.7 ± 0.2 (n = 71)	350.0 ± 64.0 (n = 9)	1277.4 ± 102.2 (n = 44)
TAK-779	6.7	6.9 (n = 1)	9.2 ± 3.67 (n = 3)	20.8 ± 2.7 (n = 9)	15.2	13.4 ± 2.1 (n = 14)