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. 2015 May;56(5):1034–1042. doi: 10.1194/jlr.P052209

Fig. 2.

Fig. 2.

Elevated IL-6 serum levels and those of IL-6 response protein CRP are significantly associated with an increase of Lp(a) in humans in vivo. This association analysis represents significant differences of Lp(a) serum levels in groups with normal (n = 955) and elevated (n = 198) IL-6 serum levels (P = 0.0015) (A). In addition, significant differences of Lp(a) serum levels in groups with normal (n = 680) and elevated (n = 473) CRP serum levels (P = 0.0018) were found (B). CRP is an IL-6-induced acute phase response protein, which suggests a major role of IL-6 regarding the relationship to Lp(a). Data are given as means + SEM, and statistical significance was tested using Mann-Whitney U-test. ** P < 0.01.