Fig. 4.

TCZ specifically inhibits LPA promoter activity in human hepatocytes. Shown is LPA (A, B) and FAS (C) promoter activity (RLU) stimulated with IL-6 (A, C) and TCZ or ADB (B) in human hepatocytes. Data are expressed in x-fold of pGL3-pLPA or pGL2-pFAS and are given as means + SEM of n = 5 independent experiments, each performed in duplicate. Statistical significance was tested using Student’s t-test, Mann-Whitney U-test, or Kruskal-Wallis test. *** P < 0.001; ns, not significant, compared with pGL3-pLPA or pGL2-pFAS.