TABLE 1.
Lipid contents in the plasma and livers
| Age 4 Weeks | Age 12 Weeks | |||
| fSS Genotype | L-SSKO Genotype | fSS Genotype | L-SSKO Genotype | |
| Plasma total cholesterol (mg/dl) | ||||
| Fed | 80.8 ± 9.0 (5) | 58.8 ± 15.1 (5)a | 85.8 ± 12.2 (6) | 55.6 ± 11.5 (7)b |
| 16 h fasted | 86.3 ± 1.44 (4) | 86.5 ± 15.0 (10) | 95.9 ± 13.2 (7) | 98.3 ± 26.2 (7) |
| Plasma triglyceride (mg/dl) | ||||
| Fed | 53.6 ± 22.3 (5) | 49.3 ± 17.0 (5) | 69.5 ± 33.2 (6) | 35.8 ± 13.2 (7)a |
| 16 h fasted | 103.8 ± 8.9 (4) | 81.1 ± 25.2 (10) | 106.2 ± 42.6 (7) | 102.5 ± 50.5 (7) |
| Plasma free fatty acid (mM) | ||||
| Fed | 0.44 ± 0.17 (5) | 0.56 ± 0.27 (5) | 0.41 ± 0.09 (6) | 0.43 ± 0.11 (7) |
| 16 h fasted | 2.13 ± 0.28 (4) | 1.63 ± 0.50 (10) | 1.50 ± 0.4 (7) | 1.58 ± 0.24 (7) |
| Hepatic cholesterol (mg/g) | 3.6 ± 0.1 (5) | 3.3 ± 0.5 (5) | 3.0 ± 0.5 (5) | 2.5 ± 0.3 (5) |
| Hepatic triglyceride (mg/g) | 4.2 ± 1.1 (5) | 6.0 ± 2.7 (5) | 5.7 ± 1.9 (5) | 6.2 ± 1.7 (5) |
| Hepatic phospholipid (mg/g) | 24.3 ± 2.1 (5) | 25.8 ± 2.1 (5) | 20.2 ± 1.8 (5) | 20.5 ± 1.8 (5) |
| Hepatic free fatty acid (μmol/g) | 4.7 ± 0.6 (5) | 4.4 ± 0.5 (5) | 5.4 ± 1.9 (5) | 4.0 ± 0.7 (5) |
Blood samples were taken from male mice fed a normal chow diet ad libitum or fasted for 16 h before the study. Each value represents the mean ± SD. Sample sizes are provided in parentheses.
a
P < 0.05 versus fSS mice with the same age by Student’s t-test.
b
P < 0.001 versus fSS mice with the same age by Student’s t-test.