Fig 6. Reduction of persistent Na+ current in an H-H formulism-based conductance model increases modulation of input-output responses by voltage fluctuations.
(A, B) Plot of steady-state membrane input resistance (A) and spike frequency (B) as a function of membrane voltage in the model for 3 different levels of INap (150 nS, 75 nS and 0 nS). (C) f-I relationships in the H-H based model using 150 nS (red), 75 nS (black) and 0 nS (cyan) with (solid line) or without (dashed line) membrane voltage fluctuations. (D) Change in firing rate resulting from membrane voltage fluctuations for low, mid and high spike rate regions of the f-I relationship. (E) Spike probability curves in the H-H based model using 150 nS (red), 75 nS (black) and 0 nS (cyan) with (solid line) or without (dashed line) membrane voltage fluctuations. (F) Plots of changes in rheobase (i) and sigmoid slope factor (ii) on spike-probability measures resulting from the introduction of membrane voltage fluctuations for the H-H based model using different levels of INap.