Table 1. Summary of the rat identification and measurements recorded during the trial including gender, number of worms recovered at necropsy, body weights prior to infection and at 6 weeks PI, spleen measurements and treatment group (C control, LD low dose, HD high dose).
| Trial | Rat ID | Gender | Number of worms* | Body wt** (g) pre-infection | Body weight (g) 6 wks PI | Change in body weight | Spleen weight (mg)* | Spleen length (mm) | Treatment |
|---|---|---|---|---|---|---|---|---|---|
| I | 42 | M | 0 | 156.0 | 176.3 | 20.3 | 162.2 | 22.0 | C |
| I | 46 | m | 0 | 169.8 | 170.2 | 0.4 | 144.8 | 21.7 | C |
| I | 71 | f | 0 | 163.8 | 198.3 | 34.5 | 277.8 | 26.8 | C |
| I | 75 | m | 0 | 150.2 | 160.7 | 10.5 | 210.0 | 22.7 | C |
| I | 80 | m | 0 | 144.5 | 170.8 | 26.3 | 196.6 | 24.2 | C |
| II | 165 | m | 0 | 157.9 | 179.6 | 21.7 | 133.0 | 25.0 | C |
| II | 157 | f | 0 | 137.4 | 115.1 | -22.3 | 295.0 | 25.0 | C |
| Mean | 167.3 | 13.1 | 202.8 | 23.9 | |||||
| I | 43 | m | 4 | 153.9 | 153.5 | -0.4 | 193.7 | 21.0 | LD |
| I | 47 | f | 2 | 140.0 | 165.8 | 25.8 | 279.9 | 26.5 | LD |
| I | 72 | f | 6 | 186.8 | 197.6 | 10.8 | 369.7 | 28.6 | LD |
| I | 76 | m | 4 | 179.7 | 190.3 | 10.6 | 421.0 | 26.5 | LD |
| I | 96 | f | 9 | 169.9 | 162.4 | -7.5 | 293.0 | 24.8 | LD |
| II | 127 | f | 0 | 150.8 | 160.2 | 9.4 | 208.0 | 22.0 | LD |
| II | 133 | m | 16 | 207.0 | 226.6 | 19.6 | 565.0 | 33.0 | LD |
| Mean | 5.9 | 179.5 | 9.8 | 332.9 | 26.1 | ||||
| I | 44 | f | 8 | 133.6 | 130.3 | -3.3 | 241.1 | 24.1 | HD |
| I | 48 | f | 21 | 133.0 | 137.2 | 4.2 | 451.4 | 28.7 | HD |
| I | 73 | f | 12 | 143.5 | 145.0 | 1.5 | 338.2 | 27.6 | HD |
| I | 77 | f | 57 | 130.8 | 128.8 | -2.0 | 350.0 | 23.6 | HD |
| I | 82 | f | 16 | 137.4 | 153.4 | 16.0 | 388.6 | 28.0 | HD |
| II | 123 | f | 47 | 145.8 | 143.8 | -2.0 | 500.0 | 28.0 | HD |
| II | 132 | m | 19 | 144.7 | 145.6 | 0.9 | 624.0 | 39.0 | HD |
| Mean | 26 | 140.6 | 2.2 | 413.3 | 28.4 |
*The mean number of adult worms isolated from HD rats was significantly greater (p = 0.001, F = 10.11, DF = 2) than those isolated from LD or C groups. The mean spleen weight of HD rats was significantly greater (p = 0.011, F = 5.92. DF = 2) than uninfected controls.
** Rats in trial I were ~5 months of age and rats in trial II were ~6 months of age at the time of body weight measurement.