Table 2.
Array | Dorsal intercalation defectivea | Total embryonic lethalityb | Ventral ruptureb | Body shape defectsb | |
---|---|---|---|---|---|
dsh-2(or302) | 100% (n=38) | 86.3% (n=51) | 58.8% (n=51) | 80.8% (n=30)e | |
Full length | 6.1% (n=33) | 14.9% (n=108) | 5.6% (n=108) | 14.9% (n=103) | |
ΔDIX | 57.1% (n=35)c | 29.4% (n=102) | 12.1% (n=102) | 31% (n=87) | |
ΔPDZ | 68.6% (n=35)c,d | 46% (n=87) | 20.7% (n=87) | 78.9% (n=71)e | |
ΔDEP | 81.5% (n=27)d | 59.5% (n=126) | 31.7% (n=126) | 58.8% (n=68) |
DSH-2 domains that are present in the constructs are as indicated.
Presence of intercalation defects as analyzed using both Nomarski imaging and confocal imaging with the junctional marker AJM-1::GFP.
Embryonic lethality, ventral rupture, and body shape defects observed in Nomarski movies of developing embryos.
Not significantly different, p=0.12.
Not significantly different, p=0.20.
Not significantly different, p=0.56.