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Predicted trajectories of Mini–Mental State Examination (MMSE) scores of patients with Alzheimer disease according to tertiles of CSF JNK3 levels. Upper tertile of JNK3: > 89 optical density units (ODU); lower tertiles of JNK3 combined: < 89 ODU. Cognitive decline was most pronounced in patients with Alzheimer disease who had low levels of CSF JNK3 (dashed line; p = 0.018).
