Table 4.

Pairwise comparisons of the regions with a significant effect of group on volume^*

	CUD v. control				NCUD v. control				CUD v. NCUD
Brain region	β†	SEβ	p value	d‡	β†	SEβ	p value	d‡	β†	SEβ	p value	d‡
Amygdala§	−276.00	34.50	< 0.001	1.24	−355.55	45.50	< 0.001	1.73	−79.60	45.46	0.08
Putamen§	−505.79	117.45	< 0.001	0.70	−926.14	154.97	< 0.001	1.33	−420.36	154.83	0.007	0.52
Insula¶	−427.10	107.9	< 0.001	0.57	−197.00	142.40	0.17		230.13	142.27	0.11
Parahippocampal gyrus	−241.71	48.25	< 0.001	0.76	−409.40	63.66	< 0.001	1.23	−167.69	63.60	0.009
Fusiform gyrus¶	−1024.10	195.80	< 0.001	0.80	−1238.32	258.38	< 0.001	0.87	−214.19	258.14	0.41

CUD = cannabis use disorder; NCUD = no cannabis use disorder; SE_β = standard error of β.

^*All results are adjusted for age, slice thickness and intracranial volume. Significant from p < 0.01.

^†Adjusted mean difference between the 2 groups.

^‡Calculated only for significant regions of interest.

^§Based on the FreeSurfer segmentation output.

^¶Based on the FreeSurfer Desikan-Killiany Atlas.