Table 2.

DAP metabolite levels for subset of 120 pregnant women from the Generation R cohort (nmol/g creatinine)^*

Meatbolite/ Period	N	# <LOQ	AM	GM	GSD	min	p5	p25	p50	p75	p95	max
DMP
<18 weeks	106	17	122.59	76.34	3.21	0.61	6.06	47.14	98.51	154.52	406.07	636.00
18–25 weeks	106	6	125.73	77.15	3.30	1.27	6.85	45.60	104.68	152.48	394.75	613.71
>25 weeks	105	9	97.46	58.86	3.60	0.83	3.85	40.99	80.74	129.50	237.44	513.75
DMTP
<18 weeks	106	2	122.94	80.37	2.73	1.30	17.89	47.30	80.82	159.55	347.93	924.31
18–25 weeks	106	2	140.10	80.17	2.95	1.11	13.35	48.96	82.04	140.01	465.71	1592.7
>25 weeks	105	1	126.68	80.34	2.81	5.83	8.89	53.20	81.02	142.05	401.71	630.4
DMDTP
<18 weeks	106	20	8.72	4.21	2.99	0.57	0.86	1.83	3.77	8.18	33.02	139.99
18–25 weeks	106	23	6.22	3.13	3.05	0.20	0.50	1.53	3.45	6.54	19.83	134.62
>25 weeks	105	20	10.00	4.06	3.28	0.41	0.62	1.80	3.82	7.41	38.80	191.94
Total DM
<18 weeks	106	-	254.25	182.97	2.36	12.43	37.09	108.82	204.56	343.24	611.47	1470.37
18–25 weeks	106	-	272.04	187.03	2.36	15.52	47.05	109.10	197.92	297.93	869.27	2126.93
>25 weeks	105	-	234.14	167.49	2.42	10.13	30.51	100.97	169.13	317.14	596.04	1098.79
DEP
<18 weeks	106	0	36.10	24.91	2.42	3.13	6.71	12.24	25.19	49.11	108.27	217.52
18–25 weeks	106	0	39.08	28.32	2.27	2.43	8.47	13.69	30.84	49.17	116.43	171.26
>25 weeks	105	1	43.68	29.67	2.67	0.42	7.07	18.19	33.05	54.15	111.00	319.32
DETP
<18 weeks	106	18	13.62	6.26	3.54	0.20	0.71	2.90	6.20	14.16	54.92	113.66
18–25 weeks	106	9	12.33	6.40	3.21	0.22	0.76	3.30	6.59	12.19	56.68	96.28
>25 weeks	105	14	18.02	7.85	3.77	0.18	0.66	3.63	7.68	20.67	55.06	257.50
DEDTP
<18 weeks	106	31	0.69	0.26	3.94	0.01	0.02	0.10	0.22	0.67	2.40	13.73
18–25 weeks	106	26	0.60	0.26	3.96	0.01	0.03	0.10	0.27	0.80	2.45	4.06
>25 weeks	105	0	1.02	0.23	4.78	0.01	0.02	0.08	0.17	0.84	2.64	43.16
Total DE
<18 weeks	106	-	50.41	34.15	2.50	3.78	8.90	16.79	33.38	69.35	158.35	222.30
18–25 weeks	106	-	52.01	37.94	2.23	5.18	10.34	21.19	38.50	65.34	158.09	203.31
>25 weeks	105	-	62.71	41.87	2.66	0.61	10.32	24.23	44.53	73.59	177.91	465.45
Total DAP
<18 weeks	106	-	304.66	228.50	2.23	29.23	50.30	133.62	261.70	405.26	698.17	1502.50
18–25 weeks	106	-	324.05	240.23	2.10	43.91	78.19	144.23	249.43	357.34	1072.21	2315.43
>25 weeks	105	-	296.85	223.95	2.23	15.85	59.64	144.38	233.22	379.71	693.49	1204.26

^*The boxplots represent the 5^th, 25^th, 50^th, 75^th and 95^th percentiles (vertical lines) as well as the outliers (dots) of the underlying distribution