Table 1. Calculated parameters from rat PK study.
| Administration Route | Dose (mg/g) | Sex | Cp (μg/ml) | Tmax (hr) | AUClast (hr.μg/ml) | MRTlast (hr) | T1/2 (hr) | V (L/kg) | CL (ml/hr/kg) |
|---|---|---|---|---|---|---|---|---|---|
| i.v. | 5 | M | 10.75 ± 0.73 | 0.14 ± 0.10 | 35.08 ± 3.48 | 3.4 ± 0.3 | 2.4 ± 0.1 | 0.48 ± 0.04 | 142 ± 17 |
| F | 11.20 ± 0.44 | 0.14 ± 0.10 | 35.42 ± 1.25 | 3.1 ± 0.0 | 2.5 ± 0.1 | 0.5 ± 0.03 | 136 ± 4 | ||
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| Administration Route | Dose (mg/g) | Sex | Cmax (μg/ml) | Tmax (hr) | AUClast (hr.μg/ml) | MRTlast (hr) | T1/2 (hr) | V (L/kg) | CL (ml/hr/kg) |
|
| |||||||||
| p.o. | 15 | M | 4.63 ± 0.20 | 4.0 ± 0.0 | 34.7 ± 3.67 | 5.9 ± 0.4 | 2.2 ± 0.3 | 0.44 ± 0.06 | 142 ± 1 |
| F | 5.84 ± 2.52 | 4.0 ± 0.0 | 57.12 ± 29.45 | 6.7 ± 0.5 | 3.1 ± 0.9 | 0.60 ± 0.16 | 136 ± 1 | ||
| 60 | M | 9.14 ± 1.76 | 5.3 ± 1.2 | 87.75 ± 35.23 | 6.9 ± 1.0 | 2.2 ± 0.3 | 0.45 ± 0.08 | 142 ± 5 | |
| F | 10.79 ± 5.03 | 5.3 ± 1.2 | 198.70 ± 142.46 | 12.5 ± 1.7 | 4.5 ± 0.8 | 0.87 ± 0.16 | 135 ± 0 | ||