. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Genes Immun. 2015 Jan 29;16(3):213–220. doi: 10.1038/gene.2014.84

Table 4.

Multivariable logistic regression model: inclusion of other covariates that are applicable to 708 subjects (HESNs and SCs) from both cohorts.

Factors^a in model	n	OR	95% CI	Adjusted P
Age >40 years	91	0.53	0.30–0.95	0.031
Female sex	370	0.94	0.65–1.34	0.721
Region (Rwanda)	222	0.34	0.14–0.86	0.023
GUI	171	3.70	2.48–5.51	<0.0001
Donor VL: >100,000 copies/mL^b	257	2.08	1.42–3.03	<0.0001
Donor VL: <10,000 copies/mL^b	166	0.37	0.22–0.61	<0.0001
HLA-B, P2-Met^c	314	1.28	0.91–1.81	0.152
rs12407485-A	263	0.52	0.37–0.75	<0.001

As defined in Table 1 and excluding 24 subjects with missing information for GUI or HIV-1 viral load (VL) in cohabiting index (donor) partners. Odds ratio (OR) and confidence interval (CI) are further adjusted for genetic ancestry (MDS1-MDS4, see text). OR >1.0 is unfavorable (being HIV-1 seropositive).

Plasma VL in known index partners (the reference group has medium plasma VL, i.e., between 10,000 and 100,000 copies/mL).

Another host genetic factor that is applicable to both cohorts,²⁸ especially in terms of time to HIV-1 acquisition (see table 5).