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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Nature. 2015 Feb 2;520(7548):553–557. doi: 10.1038/nature14156

Extended Data Figure 6. Alpha- and gamma-herpesviruses induce mtDNA stress, but RNA viruses Influenza and LCMV do not.

Extended Data Figure 6

a, Relative mtDNA copy number of WT MEFs 24 hours post infection with VSV-GFP, HSV1-GFP, or mock at the indicated MOIs. b, WT MEFs were infected with MHV68-GFP at a MOI 0.5 and after the indicated times, cells were stained and subjected to confocal microscopy or relative mtDNA copy number determined. c, WT MEFs were infected with HSV2, Flu-GFP, or LCMV-GFP, at a MOI 10, and after 6 hours, cells were stained and subjected to confocal microscopy. d, WT MEFs were infected with Vaccinia virus at a MOI 10 or 1, and after the indicated times, cells were stained and subjected to confocal microscopy or relative mtDNA copy number determined. Error bars indicate ± s.e.m. of triplicates and data are representative of two independent experiments. *=p<0.05, **=p<0.01, ***=p<0.001, ns=not significant.