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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Nature. 2015 Feb 2;520(7548):553–557. doi: 10.1038/nature14156

Figure 3. mtDNA stress potentiates viral resistance.

Figure 3

a, Viral GFP expression in MEFs infected with HSV1-GFP or VSV-GFP at MOI 0.5 for 24 hrs. b, MHV68-GFP abundance in MEFs infected at MOI 0.5. c, LCMV Armstrong gene expression 4d after i.v. infection of WT and Tfam+/− mice; n=4. d-f, Nucleoid area (d) or ISG expression (e) of MEFs exposed to ddC for 96 hrs. ddC-exposed MEFs were infected with HSV1-GFP or VSV-GFP at MOI 0.1 and imaged after 24 hrs. Error bars represent ± s.e.m. of triplicates (b,e) or quadruplicates (c) and all panels are representative of three independent experiments. **=p<0.01, ***=p<0.001.