Table II.
Reassessment of Oklahoma Registry patients who had been previously assigned to the drug-induced category
| Drug | Total number of patients |
Categories determined by re-assessment (number of patients) |
|||
|---|---|---|---|---|---|
| Definite | Probable | Possible | Unlikely | ||
| Immune-mediated TMA | |||||
| Quinine1 | 25 | 19 | 1 | 5 | - |
| Ticlopidine | 2 | - | - | 2 | - |
| Clopidogrel | 1 | - | - | 1 | - |
| Trimethoprim-sulfamethoxazole2 | 1 | - | 1 | - | - |
| Alendronate3 | 1 | - | - | 1 | - |
| Dose-dependent toxicity-mediated TMA | |||||
| Mitomycin | 11 | - | - | 11 | - |
| Cyclosporine | 4 | - | - | 4 | - |
| Tacrolimus | 4 | - | - | 3 | 1 |
| Gemcitabine | 3 | 1 | - | 2 | - |
| Carmustine | 1 | - | - | 1 | - |
| Cocaine4 | 1 | - | - | 1 | - |
| Cytarabine | 1 | - | - | 1 | - |
| “Ecstasy”5 | 1 | - | - | 1 | - |
| Pentostatin | 1 | 1 | - | - | - |
| Taxotere | 1 | - | - | 1 | - |
Data are reported for the 58 patients enrolled in the Oklahoma Registry, 1989–2014, who were initially assigned to the drug-induced clinical category. Evidence for a drug association with TMA was assessed using the criteria developed for evaluation of individual patient data for drugs with suspected immune-mediated or toxic reactions.(3) Seventeen of the 25 patients with TMA attributed to quinine and the patient with TMA attributed to pentostatin have been previously published.(7;8) Reassessment of previously published patients with TMA attributed to quinine included testing for quinine-dependent antibodies that was performed following the original publication.(8)
Twelve of the 17 previously reported patients(8) had evidence supporting a definite association with TMA; 1 patient had evidence supporting a probable association and 4 patients had evidence supporting a possible association
This patient had also taken levaquin and therefore her serum was also tested for levaquin-dependent, platelet-reactive antibodies.
This patient had also taken naproxen and therefore her serum was also tested for naproxen and naproxen glucuronide-dependent, platelet-reactive antibodies.
This patient was also tested for quinine-dependent, platelet-reactive antibodies, since quinine may be used to dilute cocaine.
MDMA (3,4-methylenedioxy-N-methylamphetamine), commonly known as Ecstasy, is an empathogenic drug of the phenethylamine and amphetamine classes of drugs.