Table 3.
Demographic, risk allele, and endothelial contributors to Brief Assessment of Cognition in Schizophrenia (BACS) Composite z-scores for 147 participants with psychotic disorders (schizophrenia, schizoaffective disorder, and psychotic disorder not otherwise specified). Race is a categorical variable comprised of Caucasian and non-Caucasian participants. Reactive Hyperemia Index (RHI) measures endothelial function and higher scores indicate endothelial dysfunction. Education is a categorical variable comprised of lower (less than high school education) and higher (high school diploma/equivalent or higher) classification groups. Risk allele group is a categorical variable compromised of participants with risk alleles (one or more of the MTHFR 667T and/or COMT 158Val variants) and participants without risk alleles (MTHFR CC and COMT Met/Met genotypes). MTHFR = methylenetetrahydrofolate reductase; COMT = catechol-o-methyl transferase.
| Predictor variable | Variable statistics | Model statistics | ||||
|---|---|---|---|---|---|---|
| β | t | p | R2 | F | p | |
| Model 1: All participants (n=147) | -- | -- | -- | 0.32 | 10.75 | <0.001 |
| Age | −0.25 | −3.56 | <0.001 | |||
| Race category | 0.22 | 2.92 | 0.004 | |||
| Education group | 0.35 | 4.89 | <0.001 | |||
| Serum folate levels | 0.12 | 1.57 | 0.118 | |||
| RHI | 0.19 | 2.65 | 0.009 | |||
| Risk allele group | 0.16 | 2.17 | 0.032 | |||
| Model 2A: No risk alleles (n=17) | -- | -- | -- | 0.25 | 0.75 | 0.603 |
| Age | −0.39 | −1.36 | 0.297 | |||
| Race category | 0.30 | 0.95 | 0.315 | |||
| Education group | 0.11 | 0.35 | 0.869 | |||
| Serum folate levels | 0.31 | 1.11 | 0.300 | |||
| RHI | 0.03 | 0.10 | 0.827 | |||
| Model 2B: Risk alleles (n=130) | -- | -- | -- | 0.33 | 12.05 | <0.001 |
| Age | −0.24 | −3.26 | 0.001 | |||
| Race category | 0.23 | 2.91 | 0.004 | |||
| Education group | 0.38 | 5.04 | <0.001 | |||
| Serum folate levels | 0.10 | 1.23 | 0.223 | |||
| RHI | 0.20 | 2.68 | 0.008 | |||