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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Schizophr Res. 2015 Feb 24;164(0):227–233. doi: 10.1016/j.schres.2015.02.009

Figure 1. Ketamine strengthens reactivated memories in a manner dependent on BLA GluN2B.

Figure 1

Low dose systemic ketamine increased freezing in PR-LTM 24hrs later only when administered prior to fear memory reactivation (A). p< 0.05 compared to vehicle. One way ANOVA F(3,44) = 4.45, p = 0.008

Enhancements in freezing due to systemic ketamine prior to auditory fear memory reactivation are due to enhanced reconsolidation as there are no differences in PR-STM 3hrs following reactivation (B ); t(14) = 0.06, p = 0.95) and specific to the reactivated memory as there are no differences in freezing to the training context 24hrs following reactivation (C; t(22) = 0.86, p = 0.41)

Blocking a known mechanisms of fear memory destabilization blocks the enhancing effect of systemic ketamine (D). * p< 0.05 compared to vehicle. Ifenprodil/vehicle infusions were completed 15min prior to ketamine/vehicle injections. Two-way ANOVA; ME Ifenprodil F(1,47) = 8.16, p=0.006; ME Ketamine F(1,47) = 2.60, p=0.11; Interaction F(1,47) = 5.56, p=0.026.