TABLE 5.

Distinct Mutations in Genes across Varying Levels of Dysplasia but from the Same Macroscopic IPMN Lesion

Pt No.	Level of dysplasia	Histologic subtype	Gene	Type of mutation	Protein change
8	High grade	Intestinal	RNF43	Frame Shift Insertion	p.R117fs
	High grade	Intestinal	RNF43	Frame Shift Deletion	p.K560fs
	Invasive	Tubular	RNF43	Frame Shift Deletion	p.L7fs
10	High grade	Pancreatobiliary	KRAS	Missense Mutation	p.G12D
	Invasive	Tubular	KRAS	Missense Mutation	p.G12V
11	High grade	Intestinal	GNAS	Missense Mutation	p.Q870L
	Low grade	Gastric	GNAS	Missense Mutation	p.R844H
	High grade	Intestinal	KRAS	Missense Mutation	p.G13D
	Low grade	Gastric	KRAS	Missense Mutation	p.G12V
13	Invasive	Tubular	KRAS	Missense Mutation	p.G12D
	Low grade	Gastric	KRAS	Missense Mutation	p.G12R
17	High grade	Intestinal	KRAS	Missense Mutation	p.G12D
	Low grade	Intestinal	KRAS	Missense Mutation	p.G12V
20	High grade	Pancreatobiliary	KRAS	Missense Mutation	p.G12R
	Invasive	Tubular	KRAS	Missense Mutation	p.G12D
44	Invasive	Tubular	KRAS	Missense Mutation	p.G12D
	Low grade	Gastric	KRAS	Missense Mutation	p.G12V
46	High grade	Pancreatobiliary	MLL2	Frame Shift Deletion	p.P2354fs
	Invasive	Tubular	MLL2	Frame Shift Insertion	p.P647fs
	High grade	Pancreatobiliary	PTEN	Frame Shift Deletion	p.L265fs
	Invasive	Tubular	PTEN	Frame Shift Deletion	p.T321fs