Figure 6. Similarity of ECoG correlation patterns across task, rest and sleep states.

A) Correlation values for task, rest and sleep states are shown for all subjects on a shared cortical surface. Correlations are relative to a consistent RSC/PCC seed location in each subject (seed). Task data reflect trial based correlation of HFB amplitude response, whereas rest and sleep data reflect correlation of spontaneous slow (< 1 Hz) fluctuations of HFB amplitude. Across all three states, a strikingly similar pattern of correlation with the AG is observed. B) Mean HFB amplitude response (400–900 ms post stimulus onset) in LPC across all subjects during the self-episodic condition, also displays a similar pattern of activation. C) To directly compare the pattern of connectivity between task, rest and sleep states, we computed the similarity between correlation matrices across each state for each subject. Example correlation matrices are shown for S3 (note outlined column in each reflects the data used for (B); i.e., a medial seed location and all lateral site correlations). D) Scatter plots show the similarity (correlation) between states for the data shown in (C) (note: to control for correlations being driven by local within region similarity, we only included the medial-lateral correlation pairs (n = 187), e.g., AG-AG or PCC-PCC pairs excluded and PCC-AG or RSC-SPL included; see Figure S8 for all pairs). Across comparisons we see a striking positive correlation between states, which is most pronounced between rest and sleep. E) Across subjects the similarity of connectivity between states is remarkably consistent. Plot shows the between state similarity (correlation value with 95% ci) for each subject and the associated correlation value for p = 0.01 based on permutation testing (S1–S3 pairs n = 196, 180, 187). See also Figures S7 and S8.