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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Mol Med (Berl). 2015 Mar 15;93(5):473–480. doi: 10.1007/s00109-015-1274-2

Figure 2.

Figure 2

Schematic illustration of dysregulation of HIF-1 and HIF-2 by chronic intermittent hypoxia (CIH) resulting from recurrent apnea and feed forward regulation of reactive oxygen species (ROS) in the carotid body chemosensory reflex pathway. Ca2+, calcium signaling, nTS, nucleus tractus solitarius, RVLM, rostral ventrolateral medulla.