Fig. 5.

Visuo-spatial orientation, spatial navigation, learning and memory in Isl2-EphA3 knock-in mice. a In the visible platform test of the Morris water maze paradigm, all three groups of mice required similar mean swimming distances per trial to reach the visible platform and showed a similar decrease in the swimming distance over consecutive trials. b During the 4-day-long training period in the hidden platform test of the Morris water maze paradigm, Isl2-EphA3 knock-in mice and their WT littermates required similar swimming distances to reach the platform and showed a similar decrease over consecutive trials. c In the 60-s probe test without platform, mice spent significantly more time in the target quadrant compared to the mean time in other quadrants regardless of their genotype. ***p < 0.0001