Fig. 5.

Predictions suggested by the model (a, c, e) and validation via in vivo data coming from new recordings of NAcc DA (b), vmPFC DA (d) and vmPFC NE (f) after 5 daily repetitions of mechanic restraint. The model shows a high degree of accuracy in predicting DA outflows in the NAcc (also including the medium experience, which matches data described in Imperato et al. 1992, 1993). It also manages to provide a less accurate but still valuable account of the DA release in the vmPFC, but it does not reproduce correctly the NE release in vmPFC