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. Author manuscript; available in PMC: 2016 Apr 23.
Published in final edited form as: Cell. 2015 Apr 23;161(3):661–673. doi: 10.1016/j.cell.2015.03.003

Figure 4. Relationship Between TF Connectivity and Human Disease.

Figure 4

(A) Cumulative distribution of TF protein-DNA interaction (PDI), protein-protein interaction (PPI) and combined degrees for essential and non-essential TFs. Combined TF degree is defined as the product of PPI and PDI degrees and represents the number of paths connecting the protein interactors of a TF with its DNA targets. Statistical significance determined by Mann-Whitney's U tests.

(B) Cumulative distribution of TF degrees for TF reported as disease-associated genes in the Human Gene Mutation Databse (HGMD) and genes not reported in HGMD. Statistical significance determined by Mann-Whitney's U tests.

(C) Correlation between TF degree and the number of protein-altering SNPs and short indel variants per 100 amino acids in cancer samples obtained from the Catalogue of Somatic mutations in Cancer (COSMIC). Statistical significance was determined using Pearson correlation coefficient.

(D) Correlation between TF degree and the number of protein-altering SNPs and short indel variants per 100 amino acids in the 1000 genomes project. Statistical significance was determined using Pearson correlation coefficient.

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