Figure 1.
(A) Transfection efficiency of Base and Guan copolymer polyplexes at various N/P ratios to cultured HeLa cells. Transfection efficiency was determined by delivering the luciferase plasmid and analyzing photon production from cell lysates. (B) Cytotoxicity of Base and Guan copolymer polyplexes at various N/P ratios to cultured HeLa cells as determined by protein content in cell lysate 48 hrs post transfection. Data shown as mean + SD (Student t-test, *p < 0.02, ** p < 0.002).