Table 1.
Minimum NAI concentration required to completely inhibit agglutination of chicken RBCs in the NAI-HI assay
| Influenza Isolates | Passage a | Oseltamivir b (nM) | Zanamivir b (nM) |
|---|---|---|---|
| Human | |||
| B/Perth/211/2001 | MDCKx | -c | - |
| A/Mississippi/3/2001 H1N1 | MDCKx | - | - |
| A/England/23/2002 H1N2 | Ex/E1 | - | - |
| A/England/23/2002 H1N2 | MDCKx/MDCK1 | - | - |
| A/Lipetsk/14/2002 H3N2 | MDCKx | 1-10 | 10-100 |
| A/Okayama/23/2004 H3N2 | MDCKx/MDCK1 | 10 | 100 |
| A/Brisbane/22/2006 H3N2 | MDCKx/MDCK1 | 1 | 10 |
| Swine and Avian | |||
| A/Swine/Nakorn Patham/2002 H3N2 | Ex/E2 | - | - |
| A/Duck/Selangor/659/2004 H3N2 | Ex/E1 | - | - |
| A/Duck/Tasmania/297/2006 H3N8 | E2 | - | - |
| A/Mallard/South Korea/12A/2006 H5N2 | E4 | - | - |
| A/Duck/Tasmania/277/2007 H7N2 | E4 | - | - |
| A/Chicken/Malacca/4905/2003 H9N2 | Ex/E2 | - | - |
aE = egg, MDCK = Madin-Darby Canine Kidney, number of passages in culture condition stated or (x) unknown number of passages.
bNAI-HI assays were performed in duplicate with 4 HAUs of virus, a final concentration of 0.5% chicken RBCs and log10 dilutions of NAIs. Where consecutive drug dilutions showed partial then full inhibition a range between these two is given.
cNo inhibition of haemagglutination (−) when tested with a maximum of 100,000 nM NAI.