Table 2.
Hemodynamic variables
| MAP = 65 mmHg | Usual MAP | P | |
|---|---|---|---|
| Norepinephrine dose (μg/kg/minute) | 0.08 (0.04-0.34) | 0.25 (0.16-0.68)* | <0.001 |
| Systolic arterial pressure (mmHg) | 107 ± 19 | 140 ± 15* | <0.001 |
| Diastolic arterial pressure (mmHg) | 53 ± 7 | 66 ± 9* | <0.001 |
| Mean arterial pressure (mmHg) | 71 ± 8 | 91 ± 7* | <0.001 |
| Heart rate (beats/minute) | 100 ± 24 | 99 ± 21 | 0.793 |
| Central venous pressure (mmHg) | 11 ± 4 | 13 ± 4* | 0.002 |
| Cardiac output (l/minute) | 5.4 ± 1.4 | 6.4 ± 2.1* | 0.001 |
| Stroke volume (ml) | 57.5 ± 21.2 | 67.0 ± 26.7* | 0.003 |
| Urine output (ml/hour) | 56 ± 6 | 55 ± 6 | 0.921 |
| Hemoglobin (g/dl) | 9.4 ± 1.9 | 9.5 ± 2.0 | 0.605 |
| Arterial pH | 7.38 ± 0.06 | 7.39 ± 0.06 | 0.305 |
| Lactate (mmol/l) | 2.3 ± 2.3 | 2.2 ± 2.3 | 0.598 |
| Arterial partial pressure of oxygen (mmHg) | 132 ± 37 | 142 ± 51 | 0.250 |
| Arterial partial pressure of carbon dioxide (mmHg) | 30 ± 6 | 29 ± 6 | 0.303 |
| Arterial hemoglobin saturation (%) | 97.4 ± 1.8 | 98.0 ± 1.6 | 0.129 |
| PaO2:FiO2 ratio (mmHg) | 259 ± 99 | 291 ± 104* | 0.003 |
| Central venous hemoglobin saturation (%) | 81 ± 7 | 83 ± 7* | 0.001 |
*P < 0.05 versus baseline of mean arterial pressure 65 mmHg. MAP, mean arterial pressure; PaO2:FiO2, arterial oxygen partial pressure to fractional inspired oxygen. Data presented as means ± SD or median (interquartile range).