Table 4.
Healthcare resource utilization during the 12 month post-index period
| Estimate* | 95% CI | P-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BFC (N = 3,697) | FSC (N = 3,697) | Lower | Upper | |||||||
| COPD-related healthcare resource utilization | ||||||||||
| COPD-related inpatient hospitalizations | ||||||||||
| Number of patients with ≥1 event (n, %) | 228 | 6.2% | 255 | 6.9% | 0.91 | 0.76 | 1.10 | 0.3466 | ||
| Number of events (mean, SD, median)1 | 1.3 | 1.1 | 1.0 | 1.2 | 0.7 | 1.0 | 0.10 | −0.08 | 0.32 | 0.3016 |
| Length of stay per patient (mean, SD, median)1 | 7.0 | 9.1 | 4.0 | 7.2 | 10.5 | 4.0 | 0.04 | −0.96 | 1.21 | 0.9485 |
| COPD-related ICU stays | ||||||||||
| Number of patients with ≥1 event (n, %) | 24 | 0.6% | 32 | 0.9% | 0.73 | 0.43 | 1.25 | 0.2564 | ||
| Number of events (mean, SD, median)1 | 1.3 | 0.7 | 1.0 | 1.1 | 0.3 | 1.0 | 0.13 | −0.33 | 0.85 | 0.6391 |
| Length of stay per patient (mean, SD, median)1 | 1.8 | 2.0 | 1.0 | 2.7 | 8.5 | 1.0 | 0.16 | −0.66 | 1.73 | 0.7661 |
| COPD-related ED visits | ||||||||||
| Number of patients with ≥1 event (n, %) | 453 | 12.3% | 438 | 11.8% | 1.08 | 0.93 | 1.24 | 0.3123 | ||
| Number of events (mean, SD, median)1 | 1.4 | 0.9 | 1.0 | 1.4 | 0.9 | 1.0 | 0.02 | −0.11 | 0.18 | 0.7462 |
| COPD-related outpatient/office visits | ||||||||||
| Number of patients with ≥1 event (n, %) | 3,047 | 82.4% | 3,072 | 83.1% | 0.93 | 0.82 | 1.05 | 0.2500 | ||
| Number of events (mean, SD, median)1 | 9.6 | 11.9 | 5.0 | 10.0 | 12.8 | 5.0 | −0.26 | −0.63 | 0.14 | 0.1966 |
| All-cause healthcare resource utilization | ||||||||||
| All-cause inpatient hospitalizations | ||||||||||
| Number of patients with ≥1 event (n, %) | 1,131 | 30.6% | 1,178 | 31.9% | 0.98 | 0.89 | 1.09 | 0.7422 | ||
| Number of events (mean, SD, median)1 | 1.9 | 1.5 | 1.0 | 2.0 | 1.7 | 1.0 | 0.04 | −0.06 | 0.14 | 0.4678 |
| Length of stay per patient (mean, SD, median)1 | 9.3 | 14.6 | 5.0 | 11.2 | 17.2 | 5.0 | −0.10 | −0.44 | 0.25 | 0.5528 |
| All-cause ICU stays | ||||||||||
| Number of patients with ≥1 event (n, %) | 220 | 6.0% | 241 | 6.5% | 0.95 | 0.78 | 1.15 | 0.5631 | ||
| Number of events (mean, SD, median)1 | 1.2 | 0.6 | 1.0 | 1.3 | 0.7 | 1.0 | 0.00 | −0.18 | 0.21 | 0.9906 |
| Length of stay per patient (mean, SD, median)1 | 2.0 | 5.5 | 1.0 | 1.9 | 4.2 | 1.0 | 0.00 | −0.22 | 0.26 | 0.9910 |
| All-cause ED visits | ||||||||||
| Number of patients with ≥1 event (n, %) | 1,012 | 27.4% | 1,003 | 27.1% | 1.05 | 0.94 | 1.16 | 0.4070 | ||
| Number of events (mean, SD, median)1 | 1.6 | 1.4 | 1.0 | 1.7 | 1.7 | 1.0 | 0.02 | −0.08 | 0.14 | 0.6778 |
| All-cause outpatient/office visits | ||||||||||
| Number of patients with ≥1 event (n, %) | 3,679 | 99.5% | 3,669 | 99.2% | 1.59 | 0.88 | 2.88 | 0.1274 | ||
| Number of events (mean, SD, median)1 | 33.1 | 30.7 | 25.0 | 34.9 | 32.3 | 27.0 | 0.03 | −0.44 | 0.52 | 0.8925 |
*: Odds ratio from logistic regression is used for dichotomous variables (0 vs.1); Odds ratio from ordinal logistic regression is used for ordinal variables (0 vs. 1 vs. 2+); mean difference from negative binomial models is used for count variables. Statistical comparisons are comparing BFC to FSC (reference group); i.e., Mean diff = mean (BFC)-mean(FSC) and OR = Odds(BFC)/Odds(FSC). Model covariates include: Sum of inpatient hospital stays >5 days (0 vs. 1), LTRA use (0, 1, 2+), geographic region, Peripheral vascular disease / atherosclerosis (0 vs. 1), index prescribing physician specialty, and analogous pre-index variable.
1: Including only patients with at least one event; length of stay defined as the number of days from admission to discharge. Same date admission and discharge were counted as one.