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. 2015 Feb 3;11(2):e1004855. doi: 10.1371/journal.pgen.1004855

Figure 1. Workflow of this study to determine the functional impact of 70 rare missense variants on LDLR protein activities and improve rare variant association testing for plasma LDL-C and the risk for early-onset MI.

Figure 1

Variants were identified through whole-exome sequencing of 3,235 individuals from the Italian Study of Early-onset Myocardial Infarction (ATVB) cohort.