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. 2015 Jan 29;34(8):1261–1276. doi: 10.1002/sim.6434

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© 2015 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A single trial realisation simulated under scenario 3 using a neighbourhood constraint. Two patients per cohort were recruited sequentially from cohort 1 (top left panel) to cohort 20 (bottom right panel). Each subfigure m = 1,…,20 shows C^*(m) (black solid line), the upper toxicity constraint (dashed red contour) based on doses whose posterior probability as well as current and past experimentation (shaded boxes) and dose-limiting toxicities (symbols). Cohort 21 (bottom left panel) additionally shows the recommended phase II doses at the end of the trial (blue boxes) as well as the true MTC_θ (dashed green line).

Inline graphic — A single trial realisation simulated under scenario 3 using a neighbourhood constraint. Two patients per cohort were recruited sequentially from cohort 1 (top left panel) to cohort 20 (bottom right panel). Each subfigure m = 1,…,20 shows C^*(m) (black solid line), the upper toxicity constraint (dashed red contour) based on doses whose posterior probability as well as current and past experimentation (shaded boxes) and dose-limiting toxicities (symbols). Cohort 21 (bottom left panel) additionally shows the recommended phase II doses at the end of the trial (blue boxes) as well as the true MTC_θ (dashed green line).