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. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Microcirculation. 2015 Feb;22(2):109–121. doi: 10.1111/micc.12183

A. Representative traces of outward K⁺ currents in LAD VSMCs evoked by steps (300 ms) to voltages over the range -70 to +70 mV with an initial holding potential of -70 mV. As highlighted by the retigabine-sensitive component a minimal increase in current was observed on application of the activator. B. Group I-V curves showing the effects of retigabine (Reti) and sequential addition of linopirdine (Lino) on K⁺ currents in LAD VSMCs (n = 5 mice, 20 cells). C. Normalized conductance plotted as a function of voltage. Curve fitting was performed using a Boltzmann function; V_1/2 values are shown in Table 3. D. Group I-V curves showing minimal effects of linopirdine on Kv7 currents under basal conditions. E. Normalized conductance plotted as a function of voltage. Curve fitting was performed using a Boltzmann function; V_1/2 values are shown in Table 3.

A. Representative traces of outward K⁺ currents in LAD VSMCs evoked by steps (300 ms) to voltages over the range -70 to +70 mV with an initial holding potential of -70 mV. As highlighted by the retigabine-sensitive component a minimal increase in current was observed on application of the activator. B. Group I-V curves showing the effects of retigabine (Reti) and sequential addition of linopirdine (Lino) on K⁺ currents in LAD VSMCs (n = 5 mice, 20 cells). C. Normalized conductance plotted as a function of voltage. Curve fitting was performed using a Boltzmann function; V_1/2 values are shown in Table 3. D. Group I-V curves showing minimal effects of linopirdine on Kv7 currents under basal conditions. E. Normalized conductance plotted as a function of voltage. Curve fitting was performed using a Boltzmann function; V_1/2 values are shown in Table 3.