TABLE 3.
Biophysical Parameters for Cerebral and LAD VSMCs
ERev | V1/2 | |
---|---|---|
Cerebral VSMCs | ||
Control | −33.9 ± 1.3 | 23.3 ± 1.9 |
+ Retigabine | −37.4 ± 1.2* | 16.2 ± 1.8* |
Retigabine sensitive# | 6.7 ± 0.9 | |
Control | −36.9 ± 1.1 | 20.7 ± 1.1 |
+ Linopirdine | −32.2 ± 1.4* | 26.4 ± 1.4* |
Linopirdine sensitive# | 8.9 ± 2.7 | |
LAD SMCs | ||
Control | −35.5 ± 2.3 | 15.6 ± 1.7 |
+ Retigabine | −37.3 ± 2.5 | 15.1 ± 1.3 |
Control | −38.7 ± 1.3 | 15.5 ± 1.6 |
+ Linopirdine | −37.7 ± 2.1 | 17.5 ± 2.2 |
sensitive components calculated by subtraction of control data and that obtained in the presence or either retigabine or linopirdine
p < 0.05 compared to control recording (paired t-test)