Table 1.
Body weight, BP, heart rate, and relative organ weights in spontaneously-hypertensive rats
| Saline group (n = 10) | ADR group (n = 16) | ADR-Cil group (n = 16) | ADR-Aml group (n = 16) | |
|---|---|---|---|---|
| BW (g) | 380 ± 4 | 299 ± 7††† | 294 ± 3 | 294 ± 2 |
| Systolic BP (mmHg) | 205 ± 4 | 183 ± 2††† | 157 ± 3*** | 154 ± 3*** |
| Heart rate (bpm) | 389 ± 15 | 460 ± 8††† | 450 ± 14 | 474 ± 12 |
| Heart weight (mg/g BW) | 3.8 ± 0.0 | 3.6 ± 0.1 | 3.5 ± 0.0*§§§ | 3.7 ± 0.0 |
| Liver weight (mg/g BW) | 40.5 ± 0.2 | 57.7 ± 1.2††† | 53.4 ± 0.7** | 53.2 ± 0.6*** |
| Lung weight (mg/g BW) | 3.3 ± 0.1 | 4.1 ± 0.1††† | 4.0 ± 0.0 | 4.1 ± 0.0 |
| Kidney weight (mg/g BW) | 7.5 ± 0.1 | 14.9 ± 0.3††† | 15.5 ± 0.2 | 15.3 ± 0.1 |
†††
P < 0.001 for the comparison with the saline group; *P < 0.05, **P < 0.01, ***P < 0.001 for the comparison with the ADR group; §§§P < 0.001 for the comparison with the ADR-Aml group.
Spontaneously-hypertensive rats were treated with ADR, followed by administration of vehicle (ADR group), 20 mg/kg per day cilnidipine (ADR-Cil group), or 3 mg/kg per day amlodipine (ADR-Aml group) for 4 weeks. Saline group received saline rather than ADR, followed by vehicle for 4 weeks.
ADR, adriamycin; Aml, amlodipine; BP, blood pressure; BW, body weight; Cil, cilnidipine.