Table 2.

Echocardiography findings in spontaneously-hypertensive rats

	Saline group (n = 10)	ADR group (n = 16)	ADR-Cil group (n = 16)	ADR-Aml group (n = 16)
Ejection fraction (%)	72.0 ± 1.4	49.7 ± 2.6†††	57.5 ± 2.2*	52.6 ± 2.6
Fractional shortening (%)	34.8 ± 1.2	20.9 ± 1.5†††	25.1 ± 1.3*	22.4 ± 1.4
Left ventricular mass (g)	1.20 ± 0.1	1.14 ± 0.02	1.06 ± 0.02*	1.13 ± 0.03
Left ventricular mass/body weight (g/g)	0.31 ± 0.0	0.39 ± 0.01†††	0.36 ± 2.2*	0.38 ± 0.01

^†††P < 0.001 for the comparison with the saline group; *P < 0.05 for the comparison with the ADR group.

Spontaneously-hypertensive rats were treated with ADR, followed by administration of vehicle (ADR group), 20 mg/kg per day cilnidipine (ADR-Cil group), or 3 mg/kg per day amlodipine (ADR-Aml group) for 4 weeks. Saline group received saline rather than ADR, followed by vehicle for 4 weeks.

ADR, adriamycin; Aml, amlodipine; BP, blood pressure; BW, body weight; Cil, cilnidipine.