Figure 1.

Some of the earlier and significant steps in the analysis of the cell biology of sexual development of Plasmodium spp.

	I	II	III	IV	V	Gamete formation	Fertilization	Ookinete	Oocyst
Light microscopy1881-	(Hawking et al., 1971; Carter and Miller, 1979)					(Laveran, 1881)	(McCallum, 1897)		(Ross, 1897)
Induction mechanisms1926-	(Sinton et al., 1926; Kafsack et al., 2014; Sinha et al., 2014)					(Billker et al., 1998)
Electron microscopy1965-	(Sinden et al., 1978)					(Garnham et al., 1967)	(Sinden et al., 1976)	(Mehlhorn et al., 1980)	(Garnham, 1965)
Nuclear organization1973-					(Janse et al., 1986b)	(Sinden et al., 1976)		(Sinden and Hartley, 1985)	(Canning and Sinden, 1973)
Transcriptome2000-	(Lanfrancotti et al., 2007)				(Hayward et al., 2000)			(Hall et al., 2005)
Translation repression1990-					(Paton et al., 1993; Guerreiro et al., 2014)		(Mair et al., 2010)
Proteins first identified1974-	(Silvestrini et al., 2005)				(Vermeulen et al., 1985)	(Kumar and Carter, 1984)	(Liu et al., 2008)	Vermeulen et al., 1985)	(Krotoski et al., 1974)
Proteome2005-					(Khan et al., 2005)	(Talman et al., 2014)		(Hall et al., 2005)
Metabolome2014-	(Lamour et al., 2014)