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. Author manuscript; available in PMC: 2015 Apr 25.
Published in final edited form as: Radiat Res. 2015 Jan 7;183(1):124–132. doi: 10.1667/RR13878.1

Figure 6. 56Fe irradiation induces clonal expansion of club progenitor cells.

Figure 6

(A) Patches of GFP lineage tags (cytoplasmic RFP, nuclear GFP, cytoplasmic YFP, membrane CFP) assessed by immunofluorescence of GFP in formalin-fixed lung tissue from tamoxifen treated Scgb1a1-CreER™; Rosa26R-Confetti mice exposed to 2.5 Gy 600 MeV/nucleon 56Fe and recovered for 70 days. (B) Quantitation of lung epithelial patches (1–2 or 3+ cells that share the same lineage tag) from unirradiated and 56Fe irradiated mice. Arrows indicate tagged cells and asterisks indicate patches. Data is presented as the relative frequency (± SEM) of patches (1–2 vs 3+) per all lineage tagged airway epithelial cells. Significance to unirradiated controls indicated by: *** (p ≤ 0.001).