Table 2.
Results of correlational analysis between physicochemical parameters, in vitro potencies at DAT and SERT, and maximal ICSS facilitation
| Physicochemical parametera | Log DAT EC50 | Log SERT EC50 | Log DAT selectivity | Maximal ICSS facilitation |
|---|---|---|---|---|
| Es | R = −0.71 | R = 0.58 | R = 0.78* | R = 0.81* |
| P = 0.07 | P = 0.17 | P = 0.04 | P = 0.03 | |
| σp | R = 0.37 | R = −0.10 | R = −0.29 | R = −0.24 |
| P = 0.42 | P = 0.84 | P = 0.53 | P = 0.61 | |
| πp | R = 0.26 | R = −0.64 | R = −0.52 | R = −0.66 |
| P = 0.57 | P = 0.12 | P = 0.23 | P = 0.11 |
*
Significant correlation.
a
Functional steric bulk, Es; electron-withdrawing capacity, σp; lipophilicity, πp. Bold styling is used to emphasize the significant correlations between Es and (i) log DAT selectivity and (ii) maximal ICSS facilitation.