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Dose-dependent analgesic effects of GDNF. GDNF or saline was administered once a day from day 7 to 9 after CCI. Mechanical allodynia and thermal hyperalgesia were assessed on the ipsilateral hind paw of CCI rats on day 10. *P < 0.05, **P < 0.01, ***P < 0.001; compared with saline. Differences in paw withdrawal threshold and latency were evaluated using the Steel test and Dunnett's test, respectively; n = 4–11.
