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Effects of the MEK inhibitor U0126 on the analgesic effects of GDNF. U0126 or vehicle was injected into the LC 30 min prior to GDNF injection. Both U0126 and GDNF were injected once a day on days 7 to 9 as indicated by the arrows. *P < 0.05, **P < 0.01, ***P < 0.001; compared with vehicle. Paw withdrawal threshold was evaluated using the Mann–Whitney U-test with Bonferroni correction, while latency was assessed using the unpaired t-test with Bonferroni correction; n = 7.
