Skip to main content
. 2015 Mar 18;172(10):2493–2506. doi: 10.1111/bph.13072

Figure 2.

Figure 2

TRPV4 channel-mediated-contraction is MAPK and Src kinase dependent. (A) TRPV4-dependent contraction in the mouse aorta (GSK101, 50 nM) is not significantly inhibited by PKC inhibitors Go6983 (0.3 μM) or GFX (0.3 μM). (B) TRPV4-dependent contraction in the mouse aorta (GSK101, 25 nM) is not inhibited by EGFR kinase inhibition (AG1478, 0.3 μM). (C) TRPV4-dependent contraction in the mouse aorta (GSK101, 50 nM) is inhibited by the MAPK inhibitor U0126 (1 μM) and Src kinase inhibitor PP1 (1 μM). Data are expressed as the mean ± SEM. n = 4–6. * P < 0.05, significantly different from response triggered by 50 nM GSK101.