Figure 2.

Means + SEM for the d2 index in the OPS on all five positions for the pilot study with untreated Wistar rats. Positions 3, 4 and 5 showed significant object location discrimination which increased with increasing distance from position 1 along the vertical axis (position 3 < 4 < 5), which is indicative of spatial pattern separation. On position 3, an increase or a decrease in pattern separation performance can be measured, that is, performance after an experimental manipulation could resemble the performance on positions 5 or 1 respectively. When compared with performance on position 1, positions 4 and 5 differed significantly with respect to pattern separation performance. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001, significantly different from chance performance/zero. n = 10–14 animals per group.