Means + SEM for the d2 index in the OPS for vehicle and donepezil treatment on positions 1 and 3. On position 1, both treatments with vehicle and with 1 mg·kg−1 donepezil showed no significant discrimination. On position 3, significant discrimination was found in both the vehicle and donepezil-treated rats. Treatment with 1 mg·kg−1 donepezil on Position 3 did show significantly better discrimination when compared with vehicle treatment on position 3. #P < 0.05; ###P < 0.001, significantly different from chance performance/zero. *P < 0.05, significantly different from the corresponding vehicle condition,. n = 23–24 animals per group.