Figure 8.
Means + SEM for the d2 index in the OPS for the effective doses of F15599 and F13714 combined on position 3. Co-administration of the effective doses of F15599 and F13714 on position 3 in the OPS task. Co-administration of 0.04 mg·kg−1 F15599 and 0.0025 mg·kg−1 F13714 led to a discrimination performance that resembled vehicle treatment on this position. In other words, combining the effective doses of these two compounds led to an increase of performance when compared with mono-treatment of 0.0025 mg·kg−1 F13714, and to a decrease of performance when compared with mono-treatment with 0.04 mg·kg−1 F15599. The vehicle and the combination of F13714 and F15599 conditions did not significantly differ in discrimination performance. (#)P = 0.08; #P < 0.05; ###P < 0.001, significantly different from chance performance/zero. *P < 0.05, significantly different from the vehicle condition,. n = 23 animals per group.