Table 1.
Morphometric and haemodynamic parameters 2 weeks after TAC or sham surgery
| Sham | Vehicle | KR36676 | Captopril | ||
|---|---|---|---|---|---|
| 10 mg·kg−1 | 30 mg·kg−1 | 30 mg·kg−1 | |||
| n | 17 | 18 | 17 | 17 | 17 |
| Body weight (g) | 23.7 ± 0.4 | 22.9 ± 0.4 | 23.5 ± 22.8 | 22.8 ± 0.3 | 23.4 ± 0.3 |
| Heart weight (mg) | 96.3 ± 1.7 | 127.8 ± 5.1* | 115.1 ± 3.1# | 108.6 ± 2.4# | 108.1 ± 2.9# |
| Ventricular weight (mg) | 92.1 ± 1.7 | 122.3 ± 4.9* | 110.1 ± 3.0# | 103.6 ± 2.5# | 103.0 ± 2.6# |
| Atrial weight (mg) | 4.2 ± 0.5 | 5.5 ± 0.5 | 4.9 ± 0.3 | 5.0 ± 0.3 | 5.1 ± 0.4 |
| Lung weight (mg) | 114.2 ± 1.4 | 117.9 ± 5.5 | 114.2 ± 2.7 | 113.8 ± 1.8 | 113.6 ± 4.8 |
| n | 10 | 6 | 7 | 7 | 6 |
| HR (beats per min) | 371.4 ± 13.9 | 398.5 ± 37.8 | 365.9 ± 17.6 | 361.0 ± 8.4 | 413.2 ± 13.5 |
| LVSP (mmHg) | 105.4 ± 4.1 | 180.0 ± 4.7* | 149.7 ± 4.5# | 141.9 ± 6.1# | 137.8 ± 10.9# |
| LVEDP (mmHg) | 6.2 ± 2.9 | 6.5 ± 4.3 | 6.7 ± 4.8 | 6.6 ± 3.1 | 6.2 ± 2.8 |
| LV +dP/dtmax (mmHg·s−1) | 6484 ± 234 | 8315 ± 275* | 6442 ± 255# | 6732 ± 203# | 6861 ± 636# |
| LV −dP/dtmax (mmHg·s−1) | −6255 ± 172 | −8305 ± 313* | −7202 ± 330 | −7439 ± 441 | −6301 ± 539# |
HR, heart rate; LV dP/dtmax, positive (+dP/dt) and negative (−dP/dt) maximum rate of pressure in left ventricle; LVSP, left ventricular systolic pressure. Data were expressed as mean ± SEM.
*
P < 0.05, significantly different from the sham group.
#
P < 0.05, significantly different from the vehicle-treated group.